Blake Beem taught domestic science in the Little Rock Public Schools 1916 through 1919. The next year she attended the University of Colorado, and in 1921 was named librarian at the Medical College of the University of Arkansas. Her successful career included serving as president of the American Library Association in 1927 and moving on to the Boston Medical Library in 1928. After four years there, her position was eliminated during the Great Depression and from 1932-1935 she worked in federal relief program for women in Little Rock. She was recruited by the University of Louisville School of Medicine library as the first experienced medical librarian at the University, and served here from 1935-1961. During her tenure, the library grew from a one-person office to a staff of eight.