Virgil Earl Simpson graduated from the University of Louisville with an A. B. and from the Hospital College of Medicine (1900). Two years later he began teaching, first at Hospital College of Medicine, later at the University of Louisville. He was on staff at Louisville City Hospital, Norton Memorial Infirmary, Kentucky Baptist Hospital, St. Joseph’s Infirmary, and Kosair Hospital for Crippled Children. He served in France with the medical corps during World War I. He was active in the Jefferson County Medical Society, the Kentucky State Medical Association and the American Medical Association, where he served in the House of Delegates as a member of the Revision Committee of the United States Pharmacopoeia.